Enfermedades inflamatorias

Artritis reumatoide

Sparks JA, O'Reilly ÉJ, Barbhaiya M, Tedeschi SK, Malspeis S, Lu B, Willett WC, Costenbader KH, Karlson EW. Association of fish intake and smoking with risk of rheumatoid arthritis and age of onset: a prospective cohort study. BMC Musculoskelet Disord. 2019 Jan 5;20(1):2. doi: 10.1186/s12891-018-2381-3.

Lourdudoss C, Di Giuseppe D, Wolk A, Westerlind H, Klareskog L, Alfredsson L, et al. Dietary Intake of Polyunsaturated Fatty Acids and Pain in Spite of Inflammatory Control Among Methotrexate-Treated Early Rheumatoid Arthritis Patients. Arthritis Care Res (Hoboken). 2018;70(2):205-12.

Elena P, Elena N. Are we really what we eat? Nutrition and its role in the onset of rheumatoid arthritis. Autoimmun Rev. 2018 Sep 10. doi: 10.1016/j.autrev.2018.05.009. [Epub ahead of print]

Beyer K, Lie SA, Kjellevold M, Dahl L, Brun JG, Bolstad AI. Marine ω-3, vitamin D levels, disease outcome and periodontal status in rheumatoid arthritis outpatients. Nutrition. 2018 Apr 4;55-56:116-124. doi: 10.1016/j.nut.2018.03.054. [Epub ahead of print] FULL TEXT

Norling LV, Headland SE, Dalli J, et al. Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI Insight. 2016;1(5):e85922.

Adeyemi WJ, Olayaki LA. Effects of single or combined administration of salmon calcitonin and omega-3 fatty acids versus diclofenac sodium in sodium monoiodoacetate-induced knee osteoarthritis in male Wistar rats. J Basic Clin Physiol Pharmacol. 2017 Sep 16.

Lourdudoss C, Wolk A, Nise L, Alfredsson L, Vollenhoven RV. Are dietary vitamin D, omega-3 fatty acids and folate associated with treatment results in patients with early rheumatoid arthritis? Data from a Swedish population-based prospective study. BMJ Open. 2017 Jun 10;7(6):e016154.

Perretti M, Norling LV. Actions of SPM in regulating host responses in arthritis. Mol Aspects Med. 2017 May 5.

Huang J, Burston JJ, Li L, Ashraf S, Mapp PI, Bennett AJ, Ravipati S, Pousinis P, Barrett DA, Scammell BE, Chapman V. Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain. Arthritis Rheumatol. 2016 Nov 16. doi: 10.1002/art.40001. [Epub ahead of print]

Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM. Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study. Rheumatology (Oxford). 2015 Sep 13.

Souza PR, Norling LV. Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. Eur J Pharmacol. 2015 Jul 9. pii: S0014-2999(15)30148-5. doi: 10.1016/j.ejphar.2015.05.072.

Proudman SM, James MJ, Spargo LD et al. Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use. Ann Rheum Dis. Published online September 30, 2013.

Lee AL, Park Y. The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women. Ann Nutr Metab. 2013 Aug 14;63(1-2):88-95.

Norling LV, Perretti M. The role of omega-3 derived resolvins in arthritis. Curr Opin Pharmacol. 2013 Jun;13(3):476-481.

Lee YH, Bae SC, Song GG. Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis. Arch Med Res. 2012 Jul;43(5):356-362.

Miles EA, Calder PC. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. Br J Nutr. 2012 Jun;107 Suppl 2:S171-84.

Gheita T, Kamel S, Helmy N et al. Omega-3 fatty acids in juvenile idiopathic arthritis: effect on cytokines (IL-1 and TNF-a), disease activity and response criteria. Clin Rheumatol. 2012 Feb;31(2):363-366.

Xu ZZ, Ji RR. Resolvins are potent analgesics for arthritic pain. Br J Pharmacol. 2011 Sep;164(2):274-277. FULL TEXT

James M, Proudman S, Cleland L. Fish oil and rheumatoid arthritis: past, present and future. Proc Nutr Soc. 2010 Aug;69(3):316-23.

Bahadori B, Uitz E, Thonhofer R, Trummer M, Pestemer-Lach I, McCarty M, Krejs GJ. omega-3 Fatty acids infusions as adjuvant therapy in rheumatoid arthritis. JPEN J Parenter Enteral Nutr. 2010 Mar-Apr;34(2):151-5.

Wann AK, Mistry J, Blain EJ et al. Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1ß-mediated cartilage degradation. Arthritis Res Ther. 2010;12(6):R207. FULL TEXT

Caughey GE, James MJ, Proudman SM et al. Fish oil supplementation increases the cyclo oxygenase inhibitory activity of paracetamol in rheumatoid arthritis patients. Complement Ther Med 2010;18:171¬174.

Hurst S, Zainal Z, Caterson B et al. Dietary fatty acids and arthritis. Prostaglandins Leukot Essent Fatty Acids 2010;82:315¬318.

Das Gupta AB, Hossain AK, Islam MH, Dey SR, Khan AL. Role of omega-3 fatty acid supplementation with indomethacin in suppression of disease activity in rheumatoid arthritis. Bangladesh Med Res Counc Bull. 2009 Aug;35(2):63-8.

Ruggiero C, Lattanzio F, Lauretani F, Gasperini B, Andres-Lacueva C, Cherubini A. Omega-3 polyunsaturated fatty acids and immune-mediated diseases: inflammatory bowel disease and rheumatoid arthritis. Curr Pharm Des. 2009;15(36):4135-48.

Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain. 2007 May;129(1-2):210-223.

Leeb BF, Sautner J, Andel I, Rintelen B. Intravenous application of omega-3 fatty acids in patients with active rheumatoid arthritis. The ORA-1 trial. An open pilot study. Lipids. 2006 Jan;41(1):29-34.

Venkatraman JT, Chu WC. Effects of dietary omega-3 and omega-6 lipids and vitamin E on serum cytokines, lipid mediators and anti-DNA antibodies in a mouse model for rheumatoid arthritis. J Am Coll Nutr. 1999 Dec;18(6):602-13.

Ariza-Ariza R, Mestanza-Peralta M, Cardiel MH. Omega-3 fatty acids in rheumatoid arthritis: an overview. Semin Arthritis Rheum. 1998 Jun;27(6):366-70.

Geusens P, Wouters C, Nijs J, Jiang Y, Dequeker J. Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study. Arthritis Rheum. 1994 Jun;37(6):824-9.

Kjeldsen-Kragh J, Lund JA, Riise T, Finnanger B, Haaland K, Finstad R, Mikkelsen K, Førre O. Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis. J Rheumatol. 1992 Oct;19(10):1531-6.

Sperling RI. Dietary omega-3 fatty acids: effects on lipid mediators of inflammation and rheumatoid arthritis. Rheum Dis Clin North Am. 1991 May;17(2):373-89.

Kremer JM. Clinical studies of omega-3 fatty acid supplementation in patients who have rheumatoid arthritis. Rheum Dis Clin North Am. 1991 May;17(2):391-402.

Astorga G, Cubillos A, Masson L, Silva JJ. Active rheumatoid arthritis: effect of dietary supplementation with omega-3 oils. A controlled double-blind trial. Rev Med Chil. 1991 Mar;119(3):267-72.

Astorga G, Cubillos A, Masson L, Silva JJ. Active rheumatoid arthritis: effect of dietary supplementation with omega-3 oils. A controlled double-blind trial. Rev Med Chil. 1991 Mar;119(3):267-72.

Enfermedad inflamatoria intestinal

Bentley-Hewitt KL, De Guzman CE, Ansell J, Mandimika T, Narbad A, Lund EK. How fish oils could support our friendly bacteria. Lipid Technology. 2015 Aug;27(8):179–82.

Zhang R, He GZ, Wang YK, Zhou KG, Ma EL. Omega-3 polyunsaturated fatty acids inhibit the increase in cytokines and chemotactic factors induced in vitro by lymph fluid from an intestinal ischemia-reperfusion injury model. Nutrition. 2015 Mar;31(3):508-14. doi: 10.1016/j.nut.2014.10.015.

Marcon R, Bento AF, Dutra RC et al. Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. J Immunol. 2013 Oct 15;191(8):4288-98. FULL TEXT

Mbodji K, Charpentier C, Guérin C et al. Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-?B in rats with TNBS-induced colitis. J Nutr Biochem. 2013 Apr;24(4):700-5.

Tabbaa M, Golubic M, Roizen MF et al. Docosahexaenoic Acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. Nutrients 2013;5(8):3299-3310. FULL TEXT

Bento AF, Claudino RF, Dutra RC et al. Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. J Immunol. 2011 Aug 15;187(4):1957-69. FULL TEXT

Turner D, Shah PS, Steinhart AH, Zlotkin S, Griffiths AM. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): A systematic review and meta-analyses. Inflamm Bowel Dis. 2010 Jun 17.

Uchiyama K, Nakamura M, Odahara S et al. N¬3 polyunsaturated fatty acid diet therapy for patients with inflammatory bowel disease. Inflamm Bowel Dis 2010;16:1696¬1707.

Ruggiero C, Lattanzio F, Lauretani F, Gasperini B, Andres-Lacueva C, Cherubini A. Omega-3 polyunsaturated fatty acids and immune-mediated diseases: inflammatory bowel disease and rheumatoid arthritis. Curr Pharm Des. 2009;15(36):4135-48.

Arrizabalaga JJ. Manejo nutricional de la enfermedad inflamatoria intestinal. Endocrinol Nutr. 2007;54:151-68. FULL TEXT

Trebble TM, Arden NK, Wootton SA, Calder PC, Mullee MA, Fine DR, Stroud MA. Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. Am J Clin Nutr. 2004;80:1137-44. FULL TEXT

Llor X. Papel de los lípidos de la dieta en los mecanismos de inflamación, proliferación, diferenciación y muerte celular en el tracto intestinal. Gastroenterol Hepatol. 2003;26:507-13. FULL TEXT

Almallah YZ, El-Tahir A, Heys SD, Richardson S, Eremin O. Distal procto-colitis and n-3 polyunsaturated fatty acids: The mechanism(s) of natural cytotoxicity inhibition. Eur J Clin Invest. 2000;30:58-65.

Almallah YZ, Ewen SW, El-Tahir A, Mowat NA, Brunt PW, Sinclair TS, Heys SD, Eremin O. Distal proctocolitis and n-3 polyunsaturated fatty acids (n-3 PUFAs): the mucosal effect in situ. J Clin Immunol. 2000 Jan;20(1):68-76.

Almallah YZ, Richardson S, O'Hanrahan T, Mowat NA, Brunt PW, Sinclair TS, Ewen S, Heys SD, Eremin O. Distal procto-colitis, natural cytotoxicity, and essential fatty acids. Am J Gastroenterol. 1998;93:804-9.

Sharon P, Stenson WF. Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology. 1984;86:453-60.


Frost BL, Caplan MS.Can Fish Oil Reduce the Incidence of Necrotizing Enterocolitis by Altering the Inflammatory Response? Clin Perinatol. 2019 Mar;46(1):65-75.

Yong K, Mori T, Chew G, Beilin LJ, Puddey I, Watts GF, Irish A, Dogra G, Boudville N, Lim W.The Effects of OMEGA-3 Fatty Acid Supplementation Upon Interleukin-12 and Interleukin-18 in Chronic Kidney Disease Patients. J Ren Nutr. 2019 Feb 22. pii: S1051-2276(19)30001-9.

Dupont J, Dedeyne L, Dalle S, Koppo K, Gielen E.The role of omega-3 in the prevention and treatment of sarcopenia. Aging Clin Exp Res. 2019 Feb 19.

Hunter DJ, James L, Hussey B, Wadley AJ, Lindley MR, Mastana SS. Impact of aerobic exercise and fatty acid supplementation on global and gene-specific DNA methylation. Epigenetics. 2019 Feb 14.

Abdolahi M, Jafarieh A, Sarraf P, Sedighiyan M, Yousefi A, Tafakhori A, Abdollahi H, Salehinia F, Djalali M. The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms. Endocr Metab Immune Disord Drug Targets. 2019 Feb 12.

Thatcher TH, Woeller CF, McCarthy CE, Sime PJ.Quenching the fires: Pro-resolving mediators, air pollution, and smoking. Pharmacol Ther. 2019 Feb 10. pii: S0163-7258(19)30014-2.

Galmés S, Cifre M, Palou A, Oliver P, Serra F. A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome. Nutrients. 2019 Jan 30;11(2).

Smith WL. A seven-step plan for becoming a moderately rich and famous biochemist. J Biol Chem. 2019 Feb 8;294(6):1779-1793.

Pecorelli A, Cervellati C, Cordone V, Amicarelli F, Hayek J, Valacchil G. 13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation. Free Radic Biol Med. 2019 Feb 8;134:598-603.

Bäck M, Hansson GK. Omega-3 fatty acids, cardiovascular risk, and the resolution of inflammation. FASEB J. 2019 Feb;33(2):1536-1539.

Schwarzkopf KM, Queck A, Thomas D, Angioni C, Cai C, Freygang Y, Rüschenbaum S, Geisslinger G, Zeuzem S, Welsch C, Lange CM.Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation. PLoS One. 2019 Jan 31;14(1)

Dushianthan A1, Cusack R, Burgess VA, Grocott MP, Calder PC. Immunonutrition for acute respiratory distress syndrome (ARDS) in adults. Cochrane Database Syst Rev. 2019 Jan 24;1

Lee KR, Midgette Y, Shah R. Fish Oil Derived Omega 3 Fatty Acids Suppress Adipose NLRP3 Inflammasome Signaling in Human Obesity. J Endocr Soc. 2018 Dec 24;3(3):504-515.

Castro-Marrero J, Zaragozá MC, Domingo JC, Martinez-Martinez A, Alegre J, von Schacky C. Low omega-3 index and polyunsaturated fatty acid status in patients with chronic fatigue syndrome/myalgic encephalomyelitis. Prostaglandins Leukot Essent Fatty Acids. 2018 Dec;139:20-24. doi: 10.1016/j.plefa.2018.11.006. Epub 2018 Nov 9.

McDougle DR, Watson JE, Abdeen AA, Adili R, Caputo MP, Krapf JE, et al. Anti-inflammatory ω-3 endocannabinoid epoxides. Proc Natl Acad Sci U S A. 2017;114(30):E6034-43.

Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta. 2010;1801(12):1260-73.

Kilburg-Basnyat B, Reece SW, Crouch MJ, Luo B, Boone AD, Yaeger M, et al. Specialized pro-resolving lipid mediators regulate ozone-induced pulmonary and systemic inflammation. Toxicol Sci. 2018 Feb 19. [Epub ahead of print]

Elajami TK, Colas RA, Dalli J, et al. Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling. FASEB J. 2016;30(8):2792-801.

Tan A, Sullenbarger B, Prakash R, McDaniel JC. Supplementation with eicosapentaenoic acid and docosahexaenoic acid reduces high levels of circulating proinflammatory cytokines in aging adults: A randomized, controlled study. Prostaglandins Leukot Essent Fatty Acids. 2018;132:23-9.

Hecker M, Sommer N, Foch S, Hecker A, Hackstein H, Witzenrath M, et al. Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation. Biochim Biophys Acta. 2018 Jun 12;1863(9):1016-28.

Serhan CN. Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology. Mol Aspects Med. 2017;58:1-11.

Caron JP, Gandy JC, Brown JL, Sordillo LM. Docosahexaenoic acid-derived oxidized lipid metabolites modulate the inflammatory response of lipolysaccharide-stimulated macrophages. Prostaglandins Other Lipid Mediat. 2018;136:76-83.

Serhan CN. Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not? Am J Pathol. 2010;177(4):1576-91.

Seki H, Sasaki T, Ueda T, et al. Resolvins as regulators of the immune system. ScientificWorldJournal. 2010;10:818-31.

Serhan CN, Petasis NA. Resolvins and Protectins in Inflammation-Resolution. Chem Rev. 2011;111(10):5922-43.

Mittal A, Ranganath V, Nichani A. Omega fatty acids and resolution of inflammation: A new twist in an old tale. J Indian Soc Periodontol. 2010;14(1):3-7.

Kohli P, Levy BD. Resolvins and protectins: mediating solutions to inflammation. Br J Pharmacol. 2009;158(4):960-71.

Serhan CN. Systems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediators. J Thromb Haemost. 2009;7Suppl 1:44-8.

Calder PC. n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006;83:1505S-19S.

Fredman G, Serhan CN. Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. Biochem J. 2011;437(2):185-97.

Serhan CN. Novel chemical mediators in the resolution of inflammation: resolvins and protectins. Anesthesiol Clin. 2006;242:341-64.

Spite M. Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. Proc Nutr Soc. 2013;72(4):441-50.

Pahlavani M, Ramalho T, Koboziev I, et al. Adipose tissue inflammation in insulin resistance: review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids. J Investig Med. 2017 Oct;65(7):1021-1027.

Rodríguez-Cruz M, Cruz-Guzmán ODR, Almeida-Becerril T, et al. Potential therapeutic impact of omega-3 long chain-polyunsaturated fatty acids on inflammation markers in Duchenne muscular dystrophy: A double-blind, controlled randomized trial. Clin Nutr. 2017 Sep 23. pii: S0261-5614(17)31343-2.

Serhan CN, Novel Pro-Resolving Lipid Mediators in Inflammation Are Leads for Resolution Physiology 2014 December 11 FULL TEXT

McDougle DR, Watson JE, Abdeen AA, Adili R, Caputo MP, Krapf JE, et al. Anti-inflammatory ω-3 endocannabinoid epoxides. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6034-E6043.

Molfino A, Amabile MI, Monti M2 Muscaritoli M. Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti-Inflammatory, Proresolving, or Both? Oxid Med Cell Longev. 2017;2017:5987082. FULL TEXT

Michalak A, Mosińska P, Fichna J. Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer. Front Pharmacol. 2016 Dec 1;7:459. FULL TEXT

Ohashi W, Hattori K, Hattori Y. Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation. J Pharmacol Exp Ther. 2015 Sep;354(3):240-50.

Calder PC. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochim Biophys Acta. 2015 Apr;1851(4):469-484. doi: 10.1016/j.bbalip.2014.08.010.

Chang HY, Lee HN, Kim W, Surh YJ. Docosahexaenoic acid induces M2 macrophage polarization through peroxisome proliferator-activated receptor γ activation. Life Sci. 2015 Jan 1;120:39-47. doi: 10.1016/j.lfs.2014.10.014.

Heemskerk MM, Dharuri HK, van den Berg SA, Jónasdóttir HS, Kloos DP, Giera M, van Dijk KW, van Harmelen V. Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile. J Lipid Res. 2014 Dec;55(12):2532-40. doi: 10.1194/jlr.M051938.

Cipollina C, Di Vincenzo S, Gerbino S, Siena L, Gjomarkaj M, Pace E. Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation. Biochim Biophys Acta. 2014 Mar 2. pii: S0304-4165(14)00085-3.

Ferguson JF, Mulvey CK, Patel PN et al. Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res. 2013 Nov 5. FULL TEXT

Yates CM, Calder PC, Ed Rainger G. Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease. Pharmacol Ther. 2013 Nov 4. pii: S0163-7258(13)00215-5.

Raphael W, Sordillo LM. Dietary polyunsaturated Fatty acids and inflammation: the role of phospholipid biosynthesis. Int J Mol Sci. 2013 Oct 22;14(10):21167-88. FULL TEXT

Alsaleh A, Crepostnaia D, Maniou Z et al. Adiponectin gene variant interacts with fish oil supplementation to influence serum adiponectin in older individuals. J Nutr. 2013 Jul;143(7):1021-7. FULL TEXT

Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol. 2013 Mar;75(3):645-662. FULL TEXT

Calder PC. Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol. 2011 Sep;668 Suppl 1:S50-8. doi: 10.1016/j.ejphar.2011.05.085. Epub 2011 Jul 28.

Skulas-Ray AC, Kris-Etherton PM, Harris WS et al. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr. 2011 Feb;93(2):243-52. FULL TEXT

Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta. 2010 Dec;1801(12):1260-73. FULL TEXT

Massaro M, Scoditti E, Carluccio MA, Campana MC, De Caterina R. Omega-3 fatty acids, inflammation and angiogenesis: basic mechanisms behind the cardioprotective effects of fish and fish oils. Cell Mol Biol (Noisy-le-grand). 2010 Feb 25;56(1):59-82.

Seki H, Sasaki T, Ueda T et al. Resolvins as regulators of the immune system. ScientificWorldJournal 2010;10:818¬831. FULL TEXT

Bannenberg GL. Resolvins: Current understanding and future potential in the control of inflammation. Curr Opin Drug Discov Devel. 2009 Sep;12(5):644-58.

Massaro M, Scoditti E, Carluccio MA, Montinari MR, De Caterina R. Omega-3 fatty acids, inflammation and angiogenesis: nutrigenomic effects as an explanation for anti-atherogenic and anti-inflammatory effects of fish and fish oils. J Nutrigenet Nutrigenomics. 2008;1(1-2):4-23. Epub 2007 Oct 17. FULL TEXT

Sijben JW, Calder PC. Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Proc Nutr Soc. 2007 May;66(2):237-59.

Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1505S-1519S. FULL TEXT

Mesa García MD, Aguilera García CM, Gil Hernández A. Importancia de los lípidos en el tratamiento nutricional de las patologías de base inflamatoria. Nutr Hosp. 2006;21(Suppl.2):30-43. FULL TEXT

Mesa García MD, Aguilera García CM, Gil Hernández A. Importancia de los lípidos en el tratamiento nutricional de las patologías de base inflamatoria. Nutr Hosp. 2006;21(Suppl.2):30-43. FULL TEXT

Lee KW, Blann AD, Lip GY. Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. Thromb Res. 2006;118(3):305-12. Epub 2005 Sep 8.

Kew S, Mesa MD, Tricon S, Buckley R, Minihane AM, Yaqoob P. Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans. Am J Clin Nutr. 2004 Apr;79(4):674-81. FULL TEXT

Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc. 2002 Aug;61(3):345-58.

Thies F, Miles EA, Nebe-von-Caron G, Powell JR, Hurst TL, Newsholme EA, Calder PC. Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults. Lipids. 2001 Nov;36(11):1183-93.


Whyand T, Hurst JR, Beckles M, Caplin ME. Pollution and respiratory disease: can diet or supplements help? A review. Respir Res. 2018;19(1):79.

de Medeiros MCS, Medeiros JCA, de Medeiros HJ, Leitão JCGC, Knackfuss MI. Dietary Intervention And Health In Patients With Systemic Lupus

Menon R, Krzyszczyk P, Berthiaume F. Pro-resolution potency of resolvins d1, d2 and e1 on neutrophil migration and in dermal wound healing. Nano Life. 2017 Mar;7(1).

Silva CAM, Belisle JT. Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis. Front Immunol. 2018 Feb 2;9:134.

Posso SV, Quesnot N, Moraes JA, Brito-Gitirana L, Kennedy-Feitosa E, Barroso MV, et al. AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway. Int Immunopharmacol. 2018;56:330-8.

Domingo P, Gallego-Escuredo JM, Fernández I, Villarroya J, Torres F, Del Mar Gutierrez M, et al. Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study. Cytokine. 2018;105:73-9.

Baker LA, Martin NRW, Kimber MC, Pritchard GJ, Lindley MR, Lewis MP. Resolvin E1 (Rv E1 ) attenuates LPS induced inflammation and subsequent atrophy in C2C12 myotubes. J Cell Biochem. 2018 Mar 25. [Epub ahead of print]

Thomas S, Browne H, Mobasheri A, Rayman MP. What is the evidence for a role for diet and nutrition in osteoarthritis? Rheumatology (Oxford). 2018;57(suppl_4):iv61-74.

Fougère B, Goisser S, Cantet C, et al; MAPT Study Group. Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study. Geroscience. 2017 Aug 22.

Smith TJ, Wilson MA, Karl JP, et al. Impact of sleep restriction on local immune response and skin barrier restoration with and without 'multi-nutrient' nutrition intervention. J Appl Physiol (1985). 2017 Sep 14:jap.00547.2017.

Zárate R, El Jaber-Vazdekis N, Tejera N, Pérez JA, Rodríguez C. Significance of long chain polyunsaturated fatty acids in human health. Clin Transl Med. 2017 Dec;6(1):25. Epub 2017 Jul 27. FULL TEXT

Gobbetti T, Dalli J, Colas RA et al. Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3963-3968.

Fougère B, de Souto Barreto P, Goisser S et al.; MAPT Study Group. Red blood cell membrane omega-3 fatty acid levels and physical performance: Cross-sectional data from the MAPT study. Clin Nutr. 2017 Apr 12. pii: S0261-5614(17)30128-0.

Serhan CN, Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology

Freitas HR, Isaac AR, Malcher-Lopes R, Diaz BL, Trevenzoli IH, De Melo Reis RA. Polyunsaturated fatty acids and endocannabinoids in health and disease. Nutr Neurosci. 2017 Jul 7:1-20. FULL TEXT

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